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NEW QUESTION # 51
Beta-thalassemia major, also known as Cooley's anemia, has inherited two genes for beta thalassemia without a normal beta-chain gene. This disease is assoicated with a marked deficiency in beta chain production and in the production of normal Hb A. These patients exhibit increased amounts of iron due to the mutliple transfusions that keep them alive. There is also a striking increase in hemoglobin F and an elevation in hemoglobin A2.
Hematology
A 5-year-old African American child with hepato-splenomegaly and skeletal abnormalities has the following lab results:
WBC = 4,800/cu.mm
20 NRBC/100 WBC
RBC = 2.70 X 106
HGB = 6.2 g/dL
Many target cells
Marked hypochromasia, anisocytosis & poikilocytosis
Serum Iron = 200 µg/dL (elevated)
Sickle Solubility = negative
Hemoglobin F = elevated
What is the PROBABLE cause of these findings?
- A. Beta-thalassemia major
- B. Sickle cell anemia
- C. Hemoglobin C disease
- D. Aplastic anemia
Answer: A
NEW QUESTION # 52
Duffy antigens are rendered inactive by enzyme treatments since the enzyme will remove the sialic acid from the RBC membrane. This process destroys: M, N, S, s, and Duffy antigens. The process enhances the reactions for Rh, Kidd, Lewis, I, and P antigens.
When performing an antibody panel, which one of the following antigens will be rendered inactive by enzyme treatment?
- A. anti-Fya
- B. anti-E
- C. anti-Jka
- D. anti-Lua
Answer: A
NEW QUESTION # 53
Glucose positive, Maltose positive, Lactose negative and Sucrose negative is the correct answer since Neisseria meningitides causes Waterhouse-Friderichsen syndrome and it is positive only for glucose and maltose.
An autopsy of a 1-year-old female admitted to the emergency room 4 hours prior to her death revealed Waterhouse-Friderichsen syndrome. Blood and nasopharyngeal cultures taken prior to her death should reveal an oxidase-positive, Gram-negative diplococcus with the following biochemical reactions:
- A. Glucose positive, Maltose positive, Lactose negative and Sucrose negative
- B. Glucose positive, Maltose positive, Sucrose positive and Lactose negative
- C. Glucose positive, Maltose positive, ONPG positive and DNase negative
- D. Glucose positive, Maltose negative, Lactose negative and Sucrose negative
Answer: A
NEW QUESTION # {0}54
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